A putative Mycobacterium tuberculosis glyoxalase Rv0801 promotes bacterial fitness by alleviating methylglyoxal stress and blunts NRF2-mediated antioxidant defenses
These findings establish Rv0801-mediated MG stress management as a critical virulence mechanism and highlight the bacterial glyoxalase as a promising target for tuberculosis therapy.
Authors
- Haiqi Chen
- Abulimiti Abudukadier
- Xinyi He (ORCID: https://orcid.org/0000-0003-4990-1777)
- Wei Wu (ORCID: https://orcid.org/0000-0002-1878-1998)
- Yun Qi
- Peibo Li
- Qun Sun
- Jianping Xie
- Qi’ao Zhang
Institutions
- Southwest University (CN)
- Ministry of Natural Resources (CN)
- Chongqing Public Health Medical Center (CN)
- Xi'an Chest Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-27
- DOI
- https://doi.org/10.3389/fimmu.2026.1745502
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Chongqing
- Centre Scientifique et Technique du Bâtiment