Serum Otolin-1 and Otoconin-90 are not elevated in vestibular migraine: a preliminary case-control study

These preliminary findings indicate that serum Otolin-1 and OC90 levels are not altered in patients with VM compared to healthy controls. Exploratory analysis revealed a phase-dependent decrease in Otolin-1 within the VM group post-attack. These results argue against significant structural damage to otoconia in VM and support a central/functional pathophysiology. While not positive diagnostic biomarkers, normal levels of these proteins may provide negative evidence to aid in differentiating VM from BPPV or MD, pending future validation.