Association of polygenic risk for cannabis use disorder with brain structure among youth with and without bipolar disorder
Present findings demonstrate a consistent pattern of higher CUD-PRS corresponding with lower regional brain structure, even in the absence of CUD. Future studies are needed to understand the mechanisms, developmental trajectories, and diagnosis-related differences in the observed findings.
Authors
- Bradley J. MacIntosh (ORCID: https://orcid.org/0000-0001-7300-2355)
- Alysha A. Sultan (ORCID: https://orcid.org/0000-0002-2718-292X)
- Clement Zai
- Benjamin I. Goldstein
- Kody G. Kennedy
- L. Trevor Young
Institutions
- Oslo University Hospital (NO)
- Centre for Addiction and Mental Health (CA)
- University of Toronto (CA)
- Ontario Brain Institute (CA)
Publication Details
- Journal
- Journal of Psychopharmacology
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1177/02698811261424206
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00