Polarization-Multiplexed Meta-Diffraction Phase Microscopy

Quantitative phase imaging has emerged as an essential tool for bioimaging, semiconductor wafer defect inspection, and material metrology. In particular, the drive toward compact and portable phase imaging systems is crucial for extending the reach of these powerful techniques to point-of-care diagnostics and inline surface profile measurement. In this work, we propose and demonstrate a polarization-multiplexed metasurface-enabled diffraction phase microscopy system for quantitative phase imaging. The metalens performs a Fourier transform and simultaneously separates two orthogonal polarizations in the Fourier plane, generating the object (x-polarized) and reference (y-polarized) waves, respectively. We first validated the system’s phase-imaging capability integrated with a standard microscope. Crucially, we then demonstrated its ability to operate as a compact, standalone system without a microscope. We envision that the proposed compact system will catalyze new applications in diverse fields, such as point-of-care diagnostics, in situ industrial monitoring, and in-line surface metrology.

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Publication Details

Journal
ACS Photonics
Published
2026-02-27
DOI
https://doi.org/10.1021/acsphotonics.5c03027
Primary Topic
Digital Holography and Microscopy
Type
article
Field-Weighted Citation Impact
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article

Polarization-Multiplexed Meta-Diffraction Phase Microscopy

Liang Gao, Zixin Zhao, Jinlong Zhu, Hui Deng et al.
ACS Photonics
Digital Holography and Microscopy
article

Polarization-Multiplexed Meta-Diffraction Phase Microscopy

Liang Gao, Zixin Zhao, Jinlong Zhu, Hui Deng, Zedi Li, Wenyu Chen
article en

Abstract

Quantitative phase imaging has emerged as an essential tool for bioimaging, semiconductor wafer defect inspection, and material metrology. In particular, the drive toward compact and portable phase imaging systems is crucial for extending the reach of these powerful techniques to point-of-care diagnostics and inline surface profile measurement. In this work, we propose and demonstrate a polarization-multiplexed metasurface-enabled diffraction phase microscopy system for quantitative phase imaging. The metalens performs a Fourier transform and simultaneously separates two orthogonal polarizations in the Fourier plane, generating the object (x-polarized) and reference (y-polarized) waves, respectively. We first validated the system’s phase-imaging capability integrated with a standard microscope. Crucially, we then demonstrated its ability to operate as a compact, standalone system without a microscope. We envision that the proposed compact system will catalyze new applications in diverse fields, such as point-of-care diagnostics, in situ industrial monitoring, and in-line surface metrology.

ACS PhotonicsVol. 13(6)
Southern University of Science and Technology (CN), Huazhong University of Science and Technology (CN)
Affordable and clean energy
Openalex Percentile: Top 41%
Digital Holography and Microscopy
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