The blaKPC-249-mediated mechanism drives the transition of ST463 Pseudomonas aeruginosa from Ceftazidime-Avibactam sensitivity to resistance during clinical treatment
These mobile genetic elements may play a role in the capture and dissemination of the <i>bla</i> <sub>KPC-249</sub> gene. The <i>bla</i> <sub>KPC-249</sub> gene is identified as a novel mutant variant of the <i>bla</i> <sub>KPC</sub> gene family, which mediates the resistance of <i>P. aeruginosa</i> to the antimicrobial agent ceftazidime-avibactam.
Authors
- Shumi Shang (ORCID: https://orcid.org/0009-0000-1876-7937)
- Feng Yan
- Heping Shen
- Huijun Liang
- Xiaoyan Wu
- Xiaosi Li
- Fupin Hu
Institutions
- Fudan University (CN)
- Jiaxing University (CN)
- First Hospital of Jiaxing (CN)
- Qujiang People's Hospital (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-02-27
- DOI
- https://doi.org/10.3389/fcimb.2026.1744386
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Zhejiang University
- Science and Technology Bureau of Jiaxing City