Case Report: Isolated acetabular myeloid sarcoma as the initial presentation of extramedullary blast crisis in chronic myeloid leukemia: a report of two cases and literature review

Through a comprehensive literature review, we identified 33 additional reported cases with the same diagnosis. This disease predominantly affects middle-aged men, with bone and parosteal soft tissues being the most common involved extramedullary site. Such patients may constitute a biologically distinct subgroup and, in some reports, have shown relatively favorable outcomes. However, our cases follow an aggressive clinical course, possibly influenced by high-risk molecular features. Large-scale clinical studies are required to clarify the biological heterogeneity of this subgroup and to optimize therapeutic strategies.