Protective Association of Endemic HCoV-NL63 With Symptomatic COVID-19 in a Pediatric Cohort
Prior HCoV-NL63 infection, but not HCoV-OC43, was associated with reduced risk of symptomatic COVID-19 in children for up to 700 days. These findings provide epidemiologic support for virus-specific cross-reactive immunity and highlight pediatric-adult differences. These findings are not yet generalizable and require validation in studies using serological markers and stricter confounder control.
Authors
- Hiroaki Fujiyasu
- Takahiro Kinebuchi
- Yutaka Saisho (ORCID: https://orcid.org/0000-0002-4387-2699)
- F Inyaku
- Hitoshi Okubo
- Fujio Kakuya
- Ryuta Terao
Institutions
- Osaka University Hospital (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- The Pediatric Infectious Disease Journal
- Published
- 2026-02-27
- DOI
- https://doi.org/10.1097/inf.0000000000005200
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00