Study on the mechanism of 18β-glycyrrhetinic acid inhibiting the proliferation of renal cancer cells by inducing autophagy through the miR-27a-5p/LC3 axis
18β-GA induces autophagy and inhibits proliferation of renal cancer cells by down-regulating miR-27a-5p and relieving its inhibition on the LC3-mediated autophagy pathway, suggesting that the miR-27a-5p/LC3 axis may be a key target for 18β-GA in the treatment of renal cancer.
Authors
- Duojie Xu (ORCID: https://orcid.org/0009-0000-8992-4688)
- Jianan Zhao (ORCID: https://orcid.org/0000-0002-8439-1082)
- Shumin Jia
- Yahong Li
- Ling Yuan
- Lei Zhang
- Ziying Zhou
- Yi Yang
- Yi Nan
- Wenjing Liu
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Ningxia Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-02-27
- DOI
- https://doi.org/10.3389/fonc.2026.1762770
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00