Effectiveness of primary tumor resection for survival after first-line cetuximab or bevacizumab in KRAS wild-type metastatic colorectal cancer treated with subsequent trifluridine/tipiracil or regorafenib

First-line cetuximab plus FOLFIRI may confer a survival advantage over bevacizumab in patients with KRAS wild-type mCRC without PTR, including during later-line therapy with trifluridine/tipiracil or regorafenib, whereas bevacizumab appears to provide more consistent benefits in those with PTR.

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Publication Details

Journal
Annals of Coloproctology
Published
2026-02-27
DOI
https://doi.org/10.3393/ac.2025.00759.0108
Primary Topic
Colorectal Cancer Treatments and Studies
Type
article
Field-Weighted Citation Impact
0.00

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article

Effectiveness of primary tumor resection for survival after first-line cetuximab or bevacizumab in KRAS wild-type metastatic colorectal cancer treated with subsequent trifluridine/tipiracil or regorafenib

YU-HSUN CHEN, Pei-Ting Lee, Chih-Chien Wu, Yi-Chia Su et al.
Annals of Coloproctology
Colorectal Cancer Treatments and Studies
article

Effectiveness of primary tumor resection for survival after first-line cetuximab or bevacizumab in KRAS wild-type metastatic colorectal cancer treated with subsequent trifluridine/tipiracil or regorafenib

YU-HSUN CHEN, Pei-Ting Lee, Chih-Chien Wu, Yi-Chia Su, Chien-Chou Su
article en

Abstract

First-line cetuximab plus FOLFIRI may confer a survival advantage over bevacizumab in patients with KRAS wild-type mCRC without PTR, including during later-line therapy with trifluridine/tipiracil or regorafenib, whereas bevacizumab appears to provide more consistent benefits in those with PTR.

Annals of ColoproctologyVol. 42(1)
National Yang Ming Chiao Tung University (TW), Kaohsiung Medical University (TW), Min-Hwei College of Health Care Management (TW), Kaohsiung Veterans General Hospital (TW), National Cheng Kung University Hospital (TW), National Cheng Kung University (TW)
National Cheng Kung University Hospital, National Cheng Kung University, Kaohsiung Veterans General Hospital
Openalex Percentile: Top 39%
Colorectal Cancer Treatments and Studies
DOIOpen Access PDFOpenAlex
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