Systematic Review of Monoclonal Antibody Therapies in Relapsing Multiple Sclerosis: Comparator-Stratified Analysis of Relapse and Disability Outcomes
this study provides a transparent synthesis of randomized evidence on monoclonal antibody therapies in relapsing MS. By explicitly accounting for network connectivity and comparator heterogeneity, the analysis avoids unsupported indirect comparisons and global treatment hierarchies. The findings support robust relapse suppression across monoclonal antibody therapies within comparable trial frameworks, while highlighting heterogeneity in disability outcomes. These results illustrate the importance of contextual interpretation in comparative effectiveness research in MS.
Authors
- Alin Ciubotaru (ORCID: https://orcid.org/0009-0003-2079-2383)
- Laura Riscanu
- Roxana Ana Covali (ORCID: https://orcid.org/0000-0002-7386-0859)
- Cristina Grosu (ORCID: https://orcid.org/0009-0006-9150-8919)
- Victor Alexandru Constantinescu
- Alexandra Maștaleru (ORCID: https://orcid.org/0000-0002-0008-9696)
- Diana Lacatusu
- Cristina Gațcan
- Albert Vamanu
- Laura-Elena Cucu (ORCID: https://orcid.org/0009-0000-1544-1325)
- Emilian Bogdan Ignat
- Robert-Valentin Bilcu
- Florina Crivoi
- Sofia Alexandra Socolov-Mihaita
- Daniel Alexa
- Alexandru Patrascu
Institutions
- Carol Davila University of Medicine and Pharmacy (RO)
- King's College London (GB)
- Grigore T. Popa University of Medicine and Pharmacy (RO)
- Apollonia University (RO)
Publication Details
- Journal
- Medical Sciences
- Published
- 2026-02-27
- DOI
- https://doi.org/10.3390/medsci14010116
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00