ZOMES: expanding roles of the PCI complexes from protein metabolism to drug discovery
The XII-ZOMES Conference (Shenzhen, 2024) showcased advances in PCI complexes—proteasome, COP9 signalosome, and eIF3—which regulate cellular proteostasis through conserved architectures. Presentations covered translation initiation, proteasome assembly, ubiquitin and ubiquitin-like modification regulation, protein quality control mechanisms, and emerging therapeutic technologies including PROTACs and molecular glues for targeted protein degradation.
Authors
- Feng Rao (ORCID: https://orcid.org/0000-0002-6038-6406)
- Lu Zhou
- Hai Rao
Institutions
- Southern University of Science and Technology (CN)
Publication Details
- Journal
- npj Metabolic Health and Disease
- Published
- 2026-02-27
- DOI
- https://doi.org/10.1038/s44324-026-00100-w
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Guangdong Science and Technology Department
- Science, Technology and Innovation Commission of Shenzhen Municipality
- Southern University of Science and Technology
- National Science and Technology Major Project