Triptolide alleviates hyperosmotic stress-induced human corneal epithelial cell damage by inhibiting NLRP3 inflammasome-mediated pyroptosis via the TLR4/NF-κB pathway
Triptolide alleviates hyperosmotic stress-induced pyroptosis and inflammatory injury in HCECs, likely through inhibiting the TLR4/NF-κB/NLRP3 pathway. This study suggests the potential of triptolide in treating hyperosmolarity-related ocular surface diseases.
Authors
- Bei Zhan
- L L Tao
- Ran Xia
Institutions
- Anhui Medical University (CN)
- Anhui Provincial Hospital (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-02-27
- DOI
- https://doi.org/10.3389/fmed.2026.1753857
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00