COL11A1 promotes lung adenocarcinoma progression via PI3K/AKT/mTOR pathway: mechanistic insights and development of a COL11A1-related prognostic signature
COL11A1 acts as an oncogene in LUAD. Its expression is transcriptionally activated by the transcription factor TWIST, and it exerts pro-tumor effects by activating the PI3K/AKT/mTOR signaling pathway. CRRS and the nomogram provide potential references for prognostic evaluation and precision treatment of LUAD patients.
Authors
- G. Z. Li
- Weijie Wu (ORCID: https://orcid.org/0009-0002-8956-5827)
- Cai Zhang
- Chenlu Gong
- Chonghua Hao
- Yujie Xiao
- Xiaoyan Li
- Xi Zhang
- Yuhang Chen
Institutions
- Central South University (CN)
- Zhoukou Normal University (CN)
- Third Xiangya Hospital (CN)
- Shanxi Provincial People’s Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-02-27
- DOI
- https://doi.org/10.3389/fonc.2026.1748723
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00