Metabolic Detoxification of Glucose and 4-Hydroxynonenal in Human Neuroblastoma Cell Models
While hyperglycemia stimulates the polyol pathway, aldehyde detoxification by AKR1B1 supports resistance to 4-HNE toxicity, demonstrating that AKR1B1 activity is essential to counteract HNE toxicity, and its impairment may increase the susceptibility of NB cells to oxidative damage.
Authors
- Francesco Balestri (ORCID: https://orcid.org/0000-0003-3758-8517)
- Roberta Moschini (ORCID: https://orcid.org/0000-0001-5227-2348)
- Gemma Sardelli (ORCID: https://orcid.org/0000-0002-3617-0496)
- G. M. Signore
- Rossella Mosca
- Martina Avanatti
- Francesca Felice
- Antonella Del Corso
Institutions
- University of Pisa (IT)
Publication Details
- Journal
- Antioxidants
- Published
- 2026-02-27
- DOI
- https://doi.org/10.3390/antiox15030298
- Primary Topic
- Aldose Reductase and Taurine
- Type
- article
- Field-Weighted Citation Impact
- 0.00