Penile involvement associated with renal pelvic squamous cell carcinoma: a case report and mechanistic considerations
This case constitutes, to our knowledge, the first reported instance of penile involvement most consistent with metastatic renal pelvic SCC. In patients with advanced upper urinary tract malignancy who develop penile lesions, secondary involvement should be considered. The absence of regional lymphadenopathy and the disseminated pattern suggest a hematogenous retrograde venous dissemination pathway.
Authors
- Rei Yoshimi
- Kensuke Hirosuna (ORCID: https://orcid.org/0000-0002-9263-4929)
- Shogo Yamazaki
- Issei Kojima
- Yuta Furusawa
- Takuya Higashio
- TAKUYA TSUJINO
- KEITA NAKAMORI
- Takeshi Tsutsumi (ORCID: https://orcid.org/0000-0002-6144-9464)
- Shuya Tsuchida
- Moritoshi Sakamoto (ORCID: https://orcid.org/0009-0000-2053-0058)
- Kengo Iwatsuki
- Masashi Sanada
- Ryoichi Maenosono
- Hiroyuki Okada
- Haruhito Azuma
- Ko Nakamura
- Yuki Nakajima
- Kotaro Masaki
- Yuki Yoshikawa
- Tatsuo Fukushima
- Tomohisa Matsunaga
- Takuya Matsuda
- Yusaku Imura
- Kazuki Nishimura
Institutions
- Osaka University of Pharmaceutical Sciences (JP)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-02-27
- DOI
- https://doi.org/10.3389/fonc.2026.1761194
- Primary Topic
- Genital Health and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science