Global, regional and national burden of colon and rectum cancer attributable to high fasting plasma glucose: a systematic analysis for the Global Burden of Disease Study 2021

The escalating burden of high FPG-driven CRC underscores its growing role in CRC epidemiology, particularly in aging populations and rapidly urbanizing regions. Persistent gender and socioeconomic disparities necessitate region-specific interventions that integrate diabetes management with CRC screening and equitable access to novel therapies. These findings advocate for prioritizing metabolic risk control in global CRC prevention frameworks to mitigate future burdens.