Immunogenicity and Protective Effects of an Ag85B Tuberculosis Subunit Vaccine Formulated with Synthetic TLR4 Agonists in BCG-Boosted Mice
Synthetic TLR4 and STING agonists were associated with enhanced immunogenicity of TB subunit vaccines and showed evidence of protective potential, with TLR4-based formulations exhibiting more pronounced immunological responses. QTP709-1 exhibited strong immunostimulatory and protective effects, supporting its potential as a candidate adjuvant for next-generation TB vaccines.
Authors
- Jin-Seung Yun
- Yong Woo Jung (ORCID: https://orcid.org/0000-0002-5599-0553)
- Soo-Min Kim (ORCID: https://orcid.org/0000-0003-4834-9941)
- You-Jin Kim
- E‐Hyun SHIN
- Hye-Sook Jeong
- Jinhee Lee
- Dokeun Kim
Institutions
- Korea University (KR)
- Korea National Institute of Health (KR)
- Korea Disease Control and Prevention Agency (KR)
Publication Details
- Journal
- Vaccines
- Published
- 2026-02-26
- DOI
- https://doi.org/10.3390/vaccines14030214
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Korea Disease Control and Prevention Agency
- Korea National Institute of Health
- Korea Centers for Disease Control and Prevention