Integrative pan-cancer analysis reveals AARS2 as a lactylation-associated biomarker and therapeutic target in colon adenocarcinoma
AARS2 correlates with lactylation dynamics, metabolic features, and immune modulation in COAD, suggesting a potential role in lactylation-associated cGAS-STING pathway regulation. These correlative observations warrant rigorous mechanistic validation to define causality and assess translational potential.
Authors
- Meiling Zou (ORCID: https://orcid.org/0000-0002-2923-210X)
- Jin Pan (ORCID: https://orcid.org/0000-0001-8699-2394)
- Shaobo Wu
- Zixuan Ding
- Yulan Song
- Yifan Fu
- Xinyue Wu
- Yixin Pan
- Wenxin Yu
Institutions
- Tongji University (CN)
- Lanzhou University Second Hospital (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-27
- DOI
- https://doi.org/10.3389/fimmu.2026.1732811
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00