RuBisCO-based CO2 fixation improves glutamate production in Corynebacterium glutamicum

This work demonstrates that "complementing" native metabolism with a CO<sub>2</sub>-fixation shunt is more effective than "replacing" essential pathways in industrial <i>C. glutamicum</i>. By successfully integrating heterologous CO<sub>2</sub> assimilation with robust industrial fermentation, this study provides a scalable and efficient blueprint for developing next-generation, carbon-negative microbial cell factories.

Authors

Institutions

Publication Details

Journal
Frontiers in Bioengineering and Biotechnology
Published
2026-02-27
DOI
https://doi.org/10.3389/fbioe.2026.1783749
Primary Topic
Microbial Metabolic Engineering and Bioproduction
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

RuBisCO-based CO2 fixation improves glutamate production in Corynebacterium glutamicum

Xixian Xie, Yulin Tang, Gang Meng, Houbo Su et al.
Frontiers in Bioengineering and Biotechnology
Microbial Metabolic Engineering and Bioproduction
article

RuBisCO-based CO2 fixation improves glutamate production in Corynebacterium glutamicum

Xixian Xie, Yulin Tang, Gang Meng, Houbo Su, Heyun Wu, Jingui Liu, Qian Ma, Aiying Wei, Chunguang Zhao
article en

Abstract

This work demonstrates that "complementing" native metabolism with a CO<sub>2</sub>-fixation shunt is more effective than "replacing" essential pathways in industrial <i>C. glutamicum</i>. By successfully integrating heterologous CO<sub>2</sub> assimilation with robust industrial fermentation, this study provides a scalable and efficient blueprint for developing next-generation, carbon-negative microbial cell factories.

Frontiers in Bioengineering and BiotechnologyVol. 14
Tianjin University of Science and Technology (CN), STR Biotech (South Korea) (KR)
National Natural Science Foundation of China, Natural Science Foundation of Tianjin City, Key Research and Development Program of Ningxia, National Key Research and Development Program of China
Openalex Percentile: Top 40%
Microbial Metabolic Engineering and Bioproduction
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.