Evaluation of genetic variation in tumor suppressor miRNA encoding and their target genes in breast cancer; focus on miRNA interaction and expression analysis
Variants rs712 and rs9266 in the KRAS 3'UTR impair miRNA binding, enhancing KRAS expression and tumorigenesis, while elevated hsa-let-7c and hsa-miR-181c levels predict favourable survival outcomes in BC patients.
Authors
- Yogita Chhichholiya
- Anjana Munshi (ORCID: https://orcid.org/0000-0002-7657-8592)
- Rajesh Vashistha (ORCID: https://orcid.org/0000-0001-6898-2440)
- Manjit Kaur Rana (ORCID: https://orcid.org/0000-0003-0791-1758)
- Sandeep Singh
Institutions
- Central University of Punjab (IN)
- Max Super Speciality Hospital (IN)
- All India Institute of Medical Sciences (IN)
Publication Details
- Journal
- Frontiers in Genome Editing
- Published
- 2026-02-27
- DOI
- https://doi.org/10.3389/fgeed.2026.1705463
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Science and Technology, Ministry of Science and Technology, India
- Council of Scientific and Industrial Research, India