Growth Differentiation Factor 15 (GDF-15) as a modulator of hepatic steatosis and fibrosis: insights from a 6-year retrospective cohort study
GDF-15 appears to modulate hepatic steatosis and fibrosis in individuals with metabolic or lifestyle risk factors, supporting its potential as a therapeutic target and warranting further investigation of the neuro-metabolic-immunologic axis.
Authors
- Dirk Alexander Wittekind (ORCID: https://orcid.org/0000-0001-5349-8189)
- Ronald Biemann (ORCID: https://orcid.org/0000-0002-0820-8231)
- Ronny Baber
- Maria Schmidt (ORCID: https://orcid.org/0000-0002-9479-3659)
- Thomas Berg
- K. Wirkner
- Michael Kluge
- Nicole Anna Dietzel
- Johannes Wiegand
Institutions
- Leipzig University of Applied Sciences (DE)
- University Medical Center (US)
- Helios Amper-Klinikum Dachau (DE)
- Life University (US)
- Leipzig University (DE)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-02-27
- DOI
- https://doi.org/10.3389/fmed.2026.1733339
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Freistaat Sachsen
- European Regional Development Fund
- European Social Fund