Aspartame exacerbates cerebral ischemia–reperfusion injury via mitochondrial dysfunction and ERK/CREB1 pathway suppression
Aspartame exacerbates CIRI-associated injury in a stress-dependent manner, involving mitochondrial dysfunction, ROS accumulation, and ERK/CREB1 suppression. Future studies are warranted to explore the long-term neurobehavioral outcomes and validate these mechanisms in clinical scenarios.
Authors
- Yuhong Li (ORCID: https://orcid.org/0000-0002-3971-7805)
- Zhi-Sheng Yao
- Ji Feng
- Yue-Tong Liu
- Guo-Dong Lu
- Kun Xue
- Xiao-Yu Wu
- Yan Bai
Institutions
- Fudan University (CN)
- Shanghai Public Health Clinical Center (CN)
Publication Details
- Journal
- Ecotoxicology and Environmental Safety
- Published
- 2026-02-27
- DOI
- https://doi.org/10.1016/j.ecoenv.2026.119938
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00