Sensitive periods of BMI change from childhood to adulthood on subclinical cardiovascular outcomes: a 36-year prospective cohort study

Rapid rates of BMI increase, particularly during childhood/adolescence, are strongly associated with a higher risk of mid-adulthood subclinical cardiovascular outcomes. These findings highlight childhood/adolescence as sensitive periods for the influence of BMI on cardiovascular disease development, emphasizing the need for early prevention and intervention.

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Publication Details

Journal
BMC Medicine
Published
2026-02-27
DOI
https://doi.org/10.1186/s12916-026-04742-x
Primary Topic
Cardiovascular Function and Risk Factors
Type
article
Field-Weighted Citation Impact
0.00
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article

Sensitive periods of BMI change from childhood to adulthood on subclinical cardiovascular outcomes: a 36-year prospective cohort study

Lili Yang, Mingfei Du, M Wang, Min He et al.
BMC Medicine
Cardiovascular Function and Risk Factors
article

Sensitive periods of BMI change from childhood to adulthood on subclinical cardiovascular outcomes: a 36-year prospective cohort study

Lili Yang, Mingfei Du, M Wang, Min He, Chao Chu, Guilin Hu, Hao Jia, Jintang Xie, Chao Li, Min Zhao, Yu Yan, Hui Yang, Dan Wang, Jianjun Mu, Jie Ren, Bo Xi, Yue Sun, Yanjie Yang
article en

Abstract

Rapid rates of BMI increase, particularly during childhood/adolescence, are strongly associated with a higher risk of mid-adulthood subclinical cardiovascular outcomes. These findings highlight childhood/adolescence as sensitive periods for the influence of BMI on cardiovascular disease development, emphasizing the need for early prevention and intervention.

BMC Medicine
Shandong University (CN), First Affiliated Hospital of Xi'an Jiaotong University (CN), Shandong Maternal and Child Health Hospital (CN), Qilu Hospital of Shandong University (CN), Xi'an Jiaotong University (CN)
Openalex Percentile: Top 46%
Cardiovascular Function and Risk Factors
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