Combination of single-cell and bulk RNA-seq reveals changes in the immune landscape in osteomyelitis
Our findings tracked the transcriptional dynamics and evolving immune landscape of osteomyelitis, highlighting macrophages as central regulators of disease progression. We identified that significant infiltration of Arg1<sup>+</sup>Sdc4<sup>+</sup>, Cxcl1<sup>+</sup>Ccl4<sup>+</sup>, and Mif<sup>+</sup>Cd63<sup>+</sup> macrophages may affect osteomyelitis through the Ccl3-Ccr1 and Cxcl2-Cxcr2 signaling pathways. These findings offer a new perspective on immune regulation in osteomyelitis.
Authors
- Jin Zheng (ORCID: https://orcid.org/0000-0001-5657-7608)
- Jun Chen (ORCID: https://orcid.org/0000-0003-0928-572X)
- Jie Tan (ORCID: https://orcid.org/0000-0002-8893-4566)
- Ji Zeng
- Xiaopeng Jing
- Zhenhua Zhu
- Siteng Li
Institutions
- Nankai University (CN)
- Third Affiliated Hospital of Southern Medical University (CN)
- Wuhan Puai Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-27
- DOI
- https://doi.org/10.3389/fimmu.2026.1746323
- Primary Topic
- Osteomyelitis and Bone Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00