Contemporary Management Strategies for Peyronie’s Disease: A Comprehensive Review

Yousif M Basheer,1 Fatma Ahmed,1 Basheer Basheer,2 Giuseppe Mucci,3 Ranjith Ramasamy4 1College of Medicine, Ajman University, Ajman, United Arab Emirates; 2College of Medicine, Jordan University of Science and Technology, Irbid, Jordan; 3Regenerative Medicine, Bioscience Institute, Falciano, San Marino; 4Urology Department, Jumeirah American Clinic, Dubai, United Arab EmiratesCorrespondence: Ranjith Ramasamy, Email [email protected]: Peyronie’s disease (PD) is an acquired fibrotic condition of the tunica albuginea that is characterized by penile curvature, deformity, pain, and impaired sexual function. PD is prevalent among all ages and is responsible for significant psychological distress. This review summarizes the current knowledge on PD, covering its epidemiology, risk factors, and natural history, along with a comprehensive overview of the medical, intralesional, and surgical options. While the traditional treatments are well-described in previous publications, the focus of the current review is on new biologic and regenerative treatments. Increasing attention to therapies such as platelet-rich plasma and stem cells is representative of the larger trend toward attempts at modifying the underlying fibrotic process, as opposed to merely correcting deformity. By integrating evolving regenerative strategies with proven therapeutic options and prioritizing patient-centered counselling, future PD care may become increasingly individualized, effective, and less invasive.Keywords: Peyronie’s disease, penile curvature, penile plaque, erectile dysfunction, review