Use of DOOR and Win-Ratio Analysis in a Secondary Evaluation of a Histoplasmosis Clinical Trial
Hierarchical composite end points may better reflect patient outcomes, rather than mortality alone. We applied DOOR and Win-Ratio analyses to a phase II trial comparing single high-dose vs standard liposomal amphotericin B for HIV-associated histoplasmosis. No clear differences were observed, supporting feasibility and informing design of future phase III trials.
Authors
- Lisandra Serra Damasceno (ORCID: https://orcid.org/0000-0003-1425-5912)
- D. Dalla-Lana
- Diego R. Falci (ORCID: https://orcid.org/0000-0002-8683-3833)
- David R. Boulware (ORCID: https://orcid.org/0000-0002-4715-0060)
- Biyue Dai (ORCID: https://orcid.org/0000-0002-4747-3687)
- Hareton Teixeira Vechi (ORCID: https://orcid.org/0000-0001-7845-3921)
- Terezinha M. J. S. Leitao
- Nathan Bahr
- Alessandro C Pasqualotto
- Marineide G Melo
- Tarsila Vieceli
- Cassia S M Godoy
- Renata B A Soares
- Monica B Bay
Institutions
- University of Minnesota (US)
- Universidade Federal do Rio Grande do Sul (BR)
- Universidade Federal de Ciências da Saúde de Porto Alegre (BR)
- Universidade Federal do Ceará (BR)
- Santa Casa Hospital (BR)
- Services Hospital (PK)
- Universidade Federal do Rio Grande do Norte (BR)
- Hospital de Clínicas de Porto Alegre (BR)
- Hospital Nossa Senhora da Conceição (BR)
- University of Minnesota Medical Center (US)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2026-02-23
- DOI
- https://doi.org/10.1093/ofid/ofag089
- Primary Topic
- Fungal Infections and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00