Integrative multi-omics and machine learning reveals the spatial niche distribution and role of CYP27A1+TAMs in immunotherapy response in non-small cell lung cancer
This study highlights the importance of spatial niches in understanding the TIME of NSCLC and predicting ICB responses. CYP27A1<sup>+</sup>TAMs and their downstream LXR pathway provide a novel research direction for exploring potential biomarkers for personalized NSCLC management.
Authors
- Yuhao Jing (ORCID: https://orcid.org/0000-0001-5834-8120)
- Qiuqiao Mu
- D. Sun
- Yuhang Jiang
- Ying Shi
- Han Zhang
- Qingsheng Liu
- Xufeng Liu
Institutions
- Tianjin University (CN)
- Tianjin People's Hospital (CN)
- Tianjin Chest Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-26
- DOI
- https://doi.org/10.3389/fimmu.2026.1782545
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00