Difficulties in Diagnosing Gastric Adenocarcinoma of the Cervix: A Clinical Case and Literature Review

We present the case of a 58-year-old patient diagnosed with gastric-type endocervical adenocarcinoma, a rare type of cervical cancer not associated with human papillomavirus (HPV) infection. The diagnosis was prompted by the incidental finding of endometrial thickening (9 mm) during a routine check-up for urinary incontinence. Hysteroscopic endometrial biopsy raised suspicion for malignancy, and further evaluation with serum CA 19-9 tumor marker and computed tomography confirmed the cervical origin of the tumor. The disease was diagnosed at an advanced stage, and despite primary treatment with chemoradiotherapy, the tumor recurred. We also provide a review of the literature focusing on the diagnostic challenges, treatment strategies, and prognosis of this rare form of cervical cancer.

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Publication Details

Journal
Cureus
Published
2026-02-26
DOI
https://doi.org/10.7759/cureus.104304
Primary Topic
Endometrial and Cervical Cancer Treatments
Type
article
Field-Weighted Citation Impact
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article

Difficulties in Diagnosing Gastric Adenocarcinoma of the Cervix: A Clinical Case and Literature Review

SANTIAGO GONZÁLEZ, Sousa Cacheiro Sousa Cacheiro, Laia Ortiz Peidro, Leornardo A Rojo Muchacho et al.
Cureus
Endometrial and Cervical Cancer Treatments
article

Difficulties in Diagnosing Gastric Adenocarcinoma of the Cervix: A Clinical Case and Literature Review

SANTIAGO GONZÁLEZ, Sousa Cacheiro Sousa Cacheiro, Laia Ortiz Peidro, Leornardo A Rojo Muchacho, Eduardo Gonzalez-Bosquet
article en

Abstract

We present the case of a 58-year-old patient diagnosed with gastric-type endocervical adenocarcinoma, a rare type of cervical cancer not associated with human papillomavirus (HPV) infection. The diagnosis was prompted by the incidental finding of endometrial thickening (9 mm) during a routine check-up for urinary incontinence. Hysteroscopic endometrial biopsy raised suspicion for malignancy, and further evaluation with serum CA 19-9 tumor marker and computed tomography confirmed the cervical origin of the tumor. The disease was diagnosed at an advanced stage, and despite primary treatment with chemoradiotherapy, the tumor recurred. We also provide a review of the literature focusing on the diagnostic challenges, treatment strategies, and prognosis of this rare form of cervical cancer.

Cureus
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Openalex Percentile: Top 38%
Endometrial and Cervical Cancer Treatments
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