Mutant Isocitrate Dehydrogenase 1 Sensitizes Intrahepatic Cholangiocarcinoma Cells to MDM2 Inhibitors
IDH1 mutation enhances MDM2 expression by inhibiting KDM5 activity to promote the proliferation of TP53wt iCCA cells. Cotargeting MDM2 and mIDH1 yields a synergistic effect on growth inhibition, providing a new strategy for treating patients with iCCA with IDH1 mutations.
Authors
- Chien-Tsung Liu
- Kung‐Chao Chang (ORCID: https://orcid.org/0000-0001-9665-5236)
- L. Chen
- Chien-Feng L Li
- Yu-chun Ma
- Yu-Hsuan Hung
- Yung-Yeh Su
- Wen-Chun Hung
- Nai-Jung Chiang
Institutions
- National Yang Ming Chiao Tung University (TW)
- Kaohsiung Medical University (TW)
- National Health Research Institutes (TW)
- Taipei Veterans General Hospital (TW)
- Chi Mei Medical Center (TW)
- National Cheng Kung University Hospital (TW)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1158/2767-9764.crc-25-0591
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00