SASdb: a comprehensive database for sex-biased alternative splicing profiles in human tissues
Alternative splicing (AS) significantly enhances transcriptomic diversity, and its dysregulation is implicated in numerous human diseases. However, no public database systematically compiles sex-related AS events across human tissues. We developed SASdb (http://www.gdbioinfo.top/sasdb), a comprehensive database contains 2,951,059 AS events and 46,418 sex-biased alternative splicing (SAS) events, covering 22 human tissues. SASdb reveals extensive sex-specific splicing patterns, offering new insights into molecular sex differences. A case study on NSCLC-specific SAS events, absent in healthy tissues, highlights their enrichment in cancer-related pathways like autophagy, GPI-anchor biosynthesis, and AMPK/mTOR signaling. SASdb's intuitive visualization supports research in sex biology and precision medicine.
Authors
- Yueqi Lu (ORCID: https://orcid.org/0000-0001-9765-7532)
- Weidong Ye (ORCID: https://orcid.org/0000-0003-0746-8290)
- Cheng Guo (ORCID: https://orcid.org/0000-0003-3452-2061)
- Zhou Hl
- You Rong Duan
- Sijia Chen
- Yongfeng Bai
- Xi Chen
- Le Xu
- Heng Xu
Institutions
- University of Electronic Science and Technology of China (CN)
- Sichuan University (CN)
- Wenzhou Medical University (CN)
- Quzhou City People's Hospital (CN)
- West China Second University Hospital of Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Quzhou University (CN)
- Zhejiang Center for Disease Control and Prevention (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1186/s13293-026-00861-5
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 0.00