P2X7R deficiency alleviates cardiac senescence by enhancing mitophagy via the HuR/TRIM26/NR4A1 axis
Our findings provide valuable insights into the role of P2X7R in cardiac ageing and identify the HuR/TRIM26/NR4A1 axis as a key signalling pathway through which P2X7R regulates cardiac ageing.
Authors
- Z Huang
- Ye B
- Yunxuan Chen (ORCID: https://orcid.org/0009-0007-3791-9933)
- Yonghua Wang (ORCID: https://orcid.org/0009-0005-6099-307X)
- Zhentong Yang
- Jiaxuan Mei
- Yixin Zhou
- Ji Zhang
- Jiaxu Shen
- Jiahui Lin
- Wenli Zhang
- Zhijie Mao
- Xin Zhong
Institutions
- Wenzhou Medical University (CN)
- Ruijin Hospital (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Jiaxing University (CN)
- First Hospital of Jiaxing (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1002/ctm2.70621
- Primary Topic
- Nuclear Receptors and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00