Dietary anthocyanins alleviate age-dependent hepatic steatosis by expanding Limosilactobacillus reuteri and modulating gut microbiota–bile acid–hepatic FXR signaling
Cy-3-G alleviates age-dependent hepatic steatosis by selectively promoting L. reuteri expansion and reshaping bile acid composition to activate hepatic FXR signaling. These findings identify a gut microbiota-mediated mechanism by which a dietary anthocyanin mitigates age-related MASLD.
Authors
- S Y Chen
- Chao Yu (ORCID: https://orcid.org/0000-0002-8096-5333)
- Xinxin Shen
- Haoyang Zhang (ORCID: https://orcid.org/0000-0002-6937-7936)
- Jie Li (ORCID: https://orcid.org/0000-0002-4366-7724)
- Jinghe Xiao
- Chen Xu (ORCID: https://orcid.org/0000-0001-6980-0581)
- Yiran You
- Tianran Shen (ORCID: https://orcid.org/0009-0002-7466-3379)
- Hongliang Xue
- Chun Wan
- Wenhua Ling
- Rong Huang
Institutions
- Hong Kong Polytechnic University (HK)
- Sun Yat-sen University (CN)
- University of Colorado Boulder (US)
- Guangdong Pharmaceutical University (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Jinan Central Hospital (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Shandong First Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Hepatology
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1097/hep.0000000000001721
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00