<i>In vivo</i> assessment of the recovery of myocardial pyruvate dehydrogenase activity following a ketogenic diet
KD-induced suppression of myocardial PDH flux is reversible, but its recovery requires significant time, with prolonged metabolic inflexibility persisting after transitioning to an ND. These finding highlight the value of in vivo assessment of cardiac PDH activity, complemented by conventional enzymatic analyses, to identify persistent metabolic inflexibility following ketogenic interventions. Such PDH inactivation may have clinical implications for heart failure or diabetes, where PDH regulation is impaired. Translating these results to humans requires consideration of slower metabolic rates, greater substrate flexibility, and higher reliance on carbohydrate oxidation, compared to rodents.
Authors
- Luke I. Szweda (ORCID: https://orcid.org/0000-0003-1858-5484)
- Jae Mo Park (ORCID: https://orcid.org/0000-0002-7404-6971)
- Joseph K. Park (ORCID: https://orcid.org/0000-0003-1699-3951)
- Zohreh Erfani (ORCID: https://orcid.org/0000-0002-6754-5684)
- Crystal Harrison (ORCID: https://orcid.org/0000-0002-8884-2805)
- Jun Chen (ORCID: https://orcid.org/0000-0002-5814-1653)
- Mai T. Huynh (ORCID: https://orcid.org/0000-0002-5545-2464)
- Abdallah Elnwasany (ORCID: https://orcid.org/0000-0002-9352-1854)
- Sarah Al Nemri (ORCID: https://orcid.org/0009-0008-8953-0230)
- Maheen Zaidi
- Xiaodong Wen
Institutions
- University of Arizona (US)
- University of Dallas (US)
- Southwestern Medical Center (US)
- Advanced Imaging Research (United States) (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1093/cvr/cvag053
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00