DPP4 inhibition affects metabolism and inflammation associated pathways in hiPSC-derived steatotic HLCs
Given the difficulties of identifying suitable anti-MAFLD drugs, novel model systems are urgently needed. Our <i>in vitro</i> HLC-model reproduced the DPP4-dependent aspects of the disease and responded positively to VILDA treatment. Further elucidation of the role of DPP4 in the etiology of MAFLD and other diseases is warranted.
Authors
- Wasco Wruck (ORCID: https://orcid.org/0000-0002-9153-7051)
- Nina Graffmann (ORCID: https://orcid.org/0000-0002-1229-0792)
- Annika Wittich (ORCID: https://orcid.org/0000-0003-0375-226X)
- Ole Pleß (ORCID: https://orcid.org/0000-0002-1468-316X)
- Christiane Loerch
- Julian Reiss
- Rabea Hokamp
- James Adjaye
Institutions
- Düsseldorf University Hospital (DE)
- Fraunhofer Institute for Translational Medicine and Pharmacology (DE)
- Heinrich Heine University Düsseldorf (DE)
- University College London (GB)
- Zayed University (AE)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-02-26
- DOI
- https://doi.org/10.3389/fcell.2026.1686556
- Citations
- 1
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 24.20
Funders
- Else Kröner-Fresenius-Stiftung
- Heinrich-Heine-Universität Düsseldorf