Insular infarction synergistically amplifies malignant cerebral edema risk in anterior circulation large vessel occlusion

Insular infarction is a potent risk multiplier, synergistically amplifying MCE risk when combined with extensive early ischemia (ASPECTS < 6) or severe deficits (NIHSS score > 14), particularly during the hyperacute phase.

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Publication Details

Journal
Journal of Stroke and Cerebrovascular Diseases
Published
2026-02-27
DOI
https://doi.org/10.1016/j.jstrokecerebrovasdis.2026.108601
Primary Topic
Acute Ischemic Stroke Management
Type
article
Field-Weighted Citation Impact
0.00

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article

Insular infarction synergistically amplifies malignant cerebral edema risk in anterior circulation large vessel occlusion

YuXi Hou, BaiYan Luo, Bing Tian, Xia Tian et al.
Journal of Stroke and Cerebrovascular Diseases
Acute Ischemic Stroke Management
article

Insular infarction synergistically amplifies malignant cerebral edema risk in anterior circulation large vessel occlusion

YuXi Hou, BaiYan Luo, Bing Tian, Xia Tian, XiaoQing Cheng, LiJun Huang, Bo Gao, LuGuang Chen, XinDao Yin, WenJing Cui, Shen Xi, HuiMin Pang, Qian Chen, Meng Zhang, JinJing Tang
article en

Abstract

Insular infarction is a potent risk multiplier, synergistically amplifying MCE risk when combined with extensive early ischemia (ASPECTS < 6) or severe deficits (NIHSS score > 14), particularly during the hyperacute phase.

Journal of Stroke and Cerebrovascular DiseasesVol. 35(4)
Guiyang Medical University (CN), Guangdong Medical College (CN), Second Military Medical University (CN), Nanjing General Hospital of Nanjing Military Command (CN), Affiliated Hospital of Guizhou Medical University (CN), Changhai Hospital (CN), Nanjing Medical University (CN), Nanjing University (CN)
Shanghai Municipal Health Commission, National Natural Science Foundation of China
Openalex Percentile: Top 42%
Acute Ischemic Stroke Management
DOIOpen Access PDFOpenAlex
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