Association between history of fertility problems and pregnancy and birth complications: A longitudinal population‐based cohort study

In this large cohort of women in Australian, initial associations between fertility problems and adverse pregnancy outcomes were attenuated after adjustment for key health and lifestyle factors. The absence of associations in fully adjusted models suggests that previously reported risks may reflect shared underlying maternal characteristics rather than infertility itself and highlights the importance of cautious interpretation of statistical significance in large observational studies.

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Publication Details

Journal
Acta Obstetricia Et Gynecologica Scandinavica
Published
2026-02-26
DOI
https://doi.org/10.1111/aogs.70178
Primary Topic
Ovarian function and disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

Association between history of fertility problems and pregnancy and birth complications: A longitudinal population‐based cohort study

Cathryn A Tully, Jessica A. Grieger, Allison M. Hodge, Danielle Schoenaker et al.
Acta Obstetricia Et Gynecologica Scandinavica
Ovarian function and disorders
article

Association between history of fertility problems and pregnancy and birth complications: A longitudinal population‐based cohort study

Cathryn A Tully, Jessica A. Grieger, Allison M. Hodge, Danielle Schoenaker, Leanne Pacella-Ince
article en

Abstract

In this large cohort of women in Australian, initial associations between fertility problems and adverse pregnancy outcomes were attenuated after adjustment for key health and lifestyle factors. The absence of associations in fully adjusted models suggests that previously reported risks may reflect shared underlying maternal characteristics rather than infertility itself and highlights the importance of cautious interpretation of statistical significance in large observational studies.

Acta Obstetricia Et Gynecologica Scandinavica
The University of Melbourne (AU), Cancer Council Victoria (AU), Hillrom (Australia) (AU), MRC Lifecourse Epidemiology Unit (GB), University of Southampton (GB), The University of Adelaide (AU)
Good health and well-being
Openalex Percentile: Top 37%
Ovarian function and disorders
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