Perioperative chemotherapy (FLOT 4 + 4) versus total neoadjuvant therapy (TNT; FLOT ×8) for resectable gastric cancer: A systematic review and exploratory meta-analysis
TNT was associated with improved chemotherapy completion without increased perioperative morbidity. However, the current evidence base is insufficient to support conclusions regarding oncologic efficacy or survival benefit.
Authors
- Moacyr Jesus Barreto de Melo Rêgo (ORCID: https://orcid.org/0000-0002-1883-6012)
- Elio Pietro Perrone
- MOHAMET AlÍ CHAOUCH
- Nagy Habib (ORCID: https://orcid.org/0000-0003-4920-4154)
- Omar Llaguna
- Alessandro Mazzotta (ORCID: https://orcid.org/0000-0001-7363-2592)
- A. Rodrigues Da Costa
- Laura Correia Jacinto
- Vitório Augusto Alexandre Alves
- Rafael Novaes Jardim
- Jayant Kumar
- Eulália Dalba Elias da Silva
Institutions
- University of Monastir (TN)
- Universidade Federal de Pernambuco (BR)
- Hammersmith Hospital (GB)
- Memorial Healthcare System (US)
- Hospital das Clínicas da Universidade Federal de Pernambuco (BR)
- Imperial College London (GB)
- Universidade Federal Rural de Pernambuco (BR)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Surgery Open Science
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1016/j.sopen.2026.02.001
- Primary Topic
- Gastric Cancer Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00