Targeted knockdown of Piezo1 in synovial macrophages attenuates osteoarthritis development
By offering experimental evidence on the role and mechanism of Piezo1 in OA synovium, this study underscores the potential of Man-LNP@Si-Piezo1 as a therapeutic strategy for OA.
Authors
- Jinglue Hu
- Yan Zheng (ORCID: https://orcid.org/0000-0003-1788-9179)
- Y Zhang
- Chengbin Huang
- Yi-Xiang Wang (ORCID: https://orcid.org/0000-0002-4021-4228)
- XuanKuai Chen
- Dengying Wu
- Haitao Guan
Institutions
- Hebei Medical University (CN)
- University of Science and Technology of China (CN)
- Peking University (CN)
- Nankai University (CN)
- Sichuan University (CN)
- Wenzhou Medical University (CN)
- Third Hospital of Hebei Medical University (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
- Peking University Third Hospital (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1016/j.jot.2026.101053
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00