Investigating the consequences of tape-stripping in ovalbumin-induced allergic mouse model: From physiology to gene regulation

This study demonstrates that tape-stripping exacerbates food allergy by disrupting epithelial barrier integrity, inducing systemic immune dysregulation, and altering gene expression in intestinal tissues. The identification of key molecular pathways and target genes-particularly <i>Acta2, Kdr, and Cxcr4</i>, which are associated with angiogenesis and inflammatory responses-reveals novel mechanistic insights into food allergy exacerbation and proposes actionable therapeutic targets for simultaneous barrier repair and immune modulation. These findings underscore the importance of the skin-gut axis in food allergy pathogenesis and offer a foundation for developing targeted interventions to manage and prevent allergic diseases. Further research is needed to validate these findings and explore therapeutic strategies targeting the identified pathways.