AGR2 promotes tumor progression by regulating macrophage polarization via the CD98hc-xCT/p-ERK pathway

AGR2 drives tumor progression by reprogramming TAMs toward an M2 phenotype and attenuating T-cell function via the CD98hc-xCT/p-ERK pathway, highlighting its potential as both a prognostic marker and a therapeutic target.

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Publication Details

Journal
Frontiers in Immunology
Published
2026-02-26
DOI
https://doi.org/10.3389/fimmu.2026.1774238
Primary Topic
Immune cells in cancer
Type
article
Field-Weighted Citation Impact
0.00

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article

AGR2 promotes tumor progression by regulating macrophage polarization via the CD98hc-xCT/p-ERK pathway

Naming Wu, L Zhao, Shan Jiang
Frontiers in Immunology
Immune cells in cancer
article

AGR2 promotes tumor progression by regulating macrophage polarization via the CD98hc-xCT/p-ERK pathway

Naming Wu, L Zhao, Shan Jiang
article en

Abstract

AGR2 drives tumor progression by reprogramming TAMs toward an M2 phenotype and attenuating T-cell function via the CD98hc-xCT/p-ERK pathway, highlighting its potential as both a prognostic marker and a therapeutic target.

Frontiers in ImmunologyVol. 17
Wuhan University (CN), Renmin Hospital of Wuhan University (CN)
Huazhong University of Science and Technology, Tongji University, Tongji Medical College, Huazhong University of Science and Technology
Openalex Percentile: Top 41%
Immune cells in cancer
DOIOpen Access PDFOpenAlex
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