Role of oral-gut microbiota dysbiosis in regulating systemic impairment during age-related obesity: an animal study
Long-term HFD is associated with systemic remodeling of the oral-gut-liver-brain axis across ages. <i>Romboutsia_B</i>, a pro-inflammatory-associated genus stably enriched in the oral and gut across all age groups, holds potential as a noninvasive microbial biomarker and candidate target for future intervention studies for obesity and its liver-brain comorbidities.
Authors
- Yu Min (ORCID: https://orcid.org/0000-0002-1469-6307)
- Junru Bai (ORCID: https://orcid.org/0000-0002-5499-0236)
- Xuemei Gao
- Xin Cong
- Yixue Tian
- Yuke Chen
Institutions
- King University (US)
- Peking University (CN)
- China-Japan Friendship Hospital (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-02-26
- DOI
- https://doi.org/10.3389/fcimb.2026.1781222
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Peking University
- National Science and Technology Major Project