Plasma ceramide Cer24:0 and insulin resistance: associations with TyG and TG/HDL-C in a multicenter study of coronary artery disease cohorts
Across complementary analytic frameworks, Cer24:0 consistently exhibited positive associations with lipid-centric IR metrics among adults with established CAD. Although observational, these findings suggest that circulating ceramide profiling-particularly Cer24:0-may refine metabolic risk stratification beyond conventional indices in cardiology practice.
Authors
- Xin Zhang (ORCID: https://orcid.org/0000-0002-2866-1092)
- Xuejiao Chen (ORCID: https://orcid.org/0000-0003-4401-8467)
- Xiaopeng Li (ORCID: https://orcid.org/0000-0001-5431-1566)
- Shuanli Xin
- Guidong Wang
- Zhijiang Xie
- Xiufeng Zhao
- Chao Chang
- Mengdan Miao
- Y Zeng
- Liang Zhang
- Rui Wang
- Junwei Wang
Institutions
- Handan College (CN)
- Hebei North University (CN)
- Beijing Anzhen Hospital (CN)
- Handa City Hospital (JP)
- Affiliated Hospital of Hebei University (CN)
- First Affiliated Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2026-02-26
- DOI
- https://doi.org/10.3389/fendo.2026.1777380
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China