Microdialysis assessment of gentamicin for second-line antimicrobial prophylaxis in abdominal surgery
This study highlights insufficient subcutaneous gentamicin exposure with standard SAP dosing. An 8 mg/kg dose improved tissue PK/PD target attainment, supporting updated dosing recommendations for beta-lactam-allergic patients. Further research is needed to validate safety and efficacy in broader populations.
Authors
- Angela Kostencovska
- Hélène Mirfendereski
- Nicolas Grégoire (ORCID: https://orcid.org/0000-0001-6436-3757)
- Sandrine Marchand
- Alexia Chauzy (ORCID: https://orcid.org/0000-0001-6443-5888)
- Matthieu Boisson
- Quentin Saint-Genis
- Nadia Teixeira
Institutions
- Université de Poitiers (FR)
- Centre Hospitalier Universitaire de Poitiers (FR)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2026-02-02
- DOI
- https://doi.org/10.1093/jac/dkag071
- Citations
- 1
- Primary Topic
- Surgical site infection prevention
- Type
- article
- Field-Weighted Citation Impact
- 39.15