Multilineage differentiation drives hamartoma formation in large-to-giant congenital melanocytic naevi: evidence for naevocyte multipotency
Hamartomas in LGCMNs originate from the LGCMN cells themselves, which undergo multipotent differentiation. LGCMNs have markedly greater stemness and multipotency than SMCMNs. Our data implicate the neuroactive ligand-receptor pathway in mediating LGCMN transdifferentiation. These findings shed light on LGCMN development and suggest that modulating differentiation pathways might offer new therapeutic approaches.
Authors
- Hai Hui Huang (ORCID: https://orcid.org/0000-0001-7430-0119)
- Haishan Lin (ORCID: https://orcid.org/0000-0002-9766-8300)
- Jianxia Meng
- Huang Xf
- Yuxin Yan
- Ran Yang (ORCID: https://orcid.org/0000-0003-3308-8224)
- Jieyu Gu
- Feng Xie (ORCID: https://orcid.org/0000-0003-3883-6930)
- Bohan Lai
- Jiamin Jin
- Danli Zhu
- Boxuan Wei
- Tao Zan
- Qingfeng Li
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Ninth People's Hospital (CN)
Publication Details
- Journal
- British Journal of Dermatology
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1093/bjd/ljaf497
- Primary Topic
- melanin and skin pigmentation
- Type
- article
- Field-Weighted Citation Impact
- 0.00