The association between major depressive disorder and cannabis use disorder: A meta-analysis and meta-regression analysis
Current-diagnosis estimates highlight a strong and clinically meaningful bidirectional association between MDD and CUD. Differences between psychiatric and community samples-especially the markedly higher current CUD prevalence in patients with MDD-underscore the need for systematic screening across treatment settings. Future work should improve diagnostic differentiation, particularly regarding the overlap between depressive symptoms and cannabis withdrawal.
Authors
- Kaê Leopoldo (ORCID: https://orcid.org/0000-0002-5541-8397)
- Maria Olívia Pozzolo Pedro (ORCID: https://orcid.org/0000-0003-1336-093X)
- João Pini Alemar (ORCID: https://orcid.org/0009-0001-6462-6868)
- João Mauricio Castaldelli-Maia
Institutions
- University of Foggia (IT)
- Universidade de São Paulo (BR)
- Faculdade de Medicina do ABC (BR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Universidad Nacional de Asunción (PY)
Publication Details
- Journal
- Journal of Psychiatric Research
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1016/j.jpsychires.2026.02.047
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00