ALKBH5 facilitates acute myeloid leukemia development and immune escape via PD-L1 regulation
ALKBH5 may promote AML progression and immune escape through the upregulation of PD-L1 and modulation of T-cell function, which provides a theoretical basis for the development and screening of novel immunotherapeutic strategies for AML.
Authors
- Haiyan Gao (ORCID: https://orcid.org/0000-0003-1405-4336)
- Xin Ma
- Le Fu
- Yuemei Feng
- Cong Zhao
- Ying Xi
- Xiangmei Ye
- Yan Wang
Institutions
- Harbin Medical University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-02-26
- DOI
- https://doi.org/10.3389/fonc.2026.1781803
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Harbin Medical University
- Health Commission of Heilongjiang Province
- Huazhong University of Science and Technology
- Tongji University