Direct Access to SCF <sub>3</sub> -Substituted 2H-Thiopyrans Via a [4 + 2] Annulation with 1,3-Dienes, AgSCF <sub>3</sub> , and KI
A [4 + 2] annulation with 1,3-dienes, AgSCF<sub>3</sub>, and KI has been established, affording a variety of CF<sub>3</sub>S-substituted 2H-thiopyrans with high chemo- and regioselectivities. The intermediate (CF<sub>3</sub>S)<sub>2</sub>C═S is generated in situ via the reaction of AgSCF<sub>3</sub> with KI under mild conditions. This method features the advantages of readily available starting materials, broad substrate scope, operational simplicity, and high atom economy.
Authors
- Yue Lu (ORCID: https://orcid.org/0000-0001-9710-7936)
- Kang Guo (ORCID: https://orcid.org/0009-0005-7316-502X)
- Fang-Fang Xu
- Jiayi Shang
- Bin Chen
Institutions
- Frontier Science Foundation (CH)
- Nanjing University (CN)
- Hebei Normal University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1021/acs.orglett.6c00389
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00