Ziyuglycoside II ameliorates chemotherapy-induced neutropenia by promoting neutrophil differentiation and functional recovery via SPI1 and C/EBPϵ transcriptional regulation
ZGSII alleviates CIN by regulating SPI1 and C/EBPϵ transcriptional activity to promote neutrophil differentiation and functional recovery. These findings provides a preclinical proof for ZGSII as a therapeutic adjuvant or alternative treatment option for CIN.
Authors
- Huan Lei (ORCID: https://orcid.org/0000-0002-9730-6481)
- Ying Zhang (ORCID: https://orcid.org/0000-0003-1620-3825)
- Haihong Fang (ORCID: https://orcid.org/0000-0001-9466-6062)
- Lin Zhang
- Chunye Cao
- Luqi Chen
- Liang Peng
- Haolin He
- Yuxiu Yang
- Lingdi Li
- Yulin Feng
Institutions
- Jiangxi University of Traditional Chinese Medicine (CN)
- Jiangxi Science and Technology Normal University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-26
- DOI
- https://doi.org/10.3389/fimmu.2026.1771161
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00