Genomic insights into antimicrobial resistance and cytotoxin production in Klebsiella oxytoca complex isolates from a nationwide Japanese surveillance program
This study provides the first nationwide integrated genomic and phenotypic analysis of the K. oxytoca complex in Japan. The spread of the multidrug-resistant, cytotoxin-producing ST176 lineage represents a previously unrecognized high-risk linage in Japan, underscoring the need for continued genomic surveillance.
Authors
- Natsumi Kawahara
- Yo Sugawara (ORCID: https://orcid.org/0000-0002-9897-3905)
- Wataru Hayashi (ORCID: https://orcid.org/0000-0003-3430-8524)
- Ikue Hayashi
- Yukari Sato (ORCID: https://orcid.org/0000-0002-9314-1974)
- Shaheem Elahi
- Motoyuki Sugai
- Koji Yahara
- Kohei Kondo
- Hui Zuo
- Sayoko Kawakami
- Liansheng Yu
- Shizuo Kayama
Institutions
- Hiroshima University (JP)
- National Institute of Infectious Diseases (JP)
- Hamanomachi Hospital (JP)
- National Institute of Health Sciences (JP)
Publication Details
- Journal
- Journal of Global Antimicrobial Resistance
- Published
- 2026-02-27
- DOI
- https://doi.org/10.1016/j.jgar.2026.02.011
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00