Evaluation of cerebral cannabinoid type 2 receptors using [11C]RSR-056 PET in a rat model of epilepsy
CB2R-targeted PET probe [<sup>11</sup>C]RSR-056 enables non-invasive visualization of spatiotemporal changes in brain CB2R expression of living epileptic rats. CB2R expression elevated at 1 d post SE, peaked at 1 w post SE, and declined to baseline at 1 m and 2 m post SE. Elevated CB2R expression was associated not only with microglia but also with neurons.
Authors
- Huiyi Wei
- Guixian Tang (ORCID: https://orcid.org/0000-0001-7401-0963)
- Kin Liao (ORCID: https://orcid.org/0000-0001-6352-2349)
- Lu Hou (ORCID: https://orcid.org/0009-0005-7559-7256)
- Weijian Ye (ORCID: https://orcid.org/0000-0002-0457-3565)
- Jian Gong (ORCID: https://orcid.org/0000-0002-5643-2633)
- Xueying Ling
- Hao Xu
- Zhiqiang Tan
- Yuanfang Jiang
- Honghao Zhu
- Biao Wu
- Huanhua Wu
- Chunyuan Zeng
- Chenchen Dong
Institutions
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2026-02-27
- DOI
- https://doi.org/10.1016/j.brainresbull.2026.111799
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00